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Publications

2021

Shima  Ghoroghi, Benjamin Mary, Annabel Larnicol, Annick Klein, Naël Osmani, Ignacio Busnelli, François Delalande, Nicodème Paul, Sébastien Halary, Fréderic Gros, Laetitia Fouillen, Anne-Marie Haeberle, Cathy Royer, Coralie Spiegelhalter, Gwennan André-Grégoire, Vincent Mittelheiser, Alexandre Detappe, Kendelle Murphy, Paul Timpson, Raphaël Carapito, Marcel Blot-Chabaud, Julie Gavard, Christine Carapito, Nicolas Vitale, Olivier Lefebvre, Jacky G. Goetz*, Vincent Hyenne* (*Co-corresponding authors). Ral GTPases promote metastasis by controlling biogenesis and organotropism of exosomes. eLife, 2021, Jan 6;10:e61539
BiorXiv: https://www.biorxiv.org/content/10.1101/2020.07.10.196691v1.

Fei Liu, Yosuke Niko, Redouane Bouchaala, Luc Mercier, Olivier Lefebvre, Bohdan Andreiuk, Thierry Vandamme, Jacky G Goetz, Nicolas Anton, Andrey S Klymchenko. Drug‐sponge lipid nanocarrier for in situ cargo loading and release using dynamic covalent chemistry. Angewandte Chemie 2021, 60, 2-11.

Benjamin Mary, Shima Ghoroghi, Vincent Hyenne and Jacky G. Goetz. Live tracking of extracellular vesicles in larval zebrafish. Methods in Enzymology In press

Naël Osmani, Gautier Follain, Valentin Gensbittel, Garcia-Leon MJ, Sébastien Harlepp, Jacky G.Goetz. Probing intravascular adhesion and extravasation of tumor cells with microfluidics. Methods in Molecular Biology In press, 2020

Valentin Gensbittel, Ignacio Busnelli, Nael Osmani* and Jacky G. Goetz*. Nanoluminal Sigalings shaphes collective metastasis. Trends in Cancer 2021 Jan;7(1):9-11

Raphael Gaudin et Jacky G.Goetz. Tracking mechanisms of viral dissemination in vivo. Trends in Cell Biology. 2021 Jan;31(1):17-23

2020

Krummel M, Hu K, de Vries EGE, Goetz JG, Passaro D, Subramaniam S, Misteli T, Skala M, Bravo-Cordero JJ, Sutcliffe JL. Visualizing CancerCancer Cell 2020 Dec 14;38(6):753-756

Valentin Gensbittel, Martin Kräter,Sébastien Harlepp, Ignacio Busnelli, Jochen Guck* and Jacky G. Goetz*. The mechanical journey of a successful metastatic cancer cell. Developmental Cell 2020 Nov 3:S1534-5807(20)30801-7.

M Perro, JG Goetz, A Peixoto. Intravital Microscopy. Imaging from Cells to Animals in Vivo In press (2020) Book chapter

Gautier Follain, Valentin Gensbittel, Benjamin Mary, Olivier Lefebvre, Sébastien Harlepp, Vincent Hyenne , Jacky G. Goetz. Influence de la mécanique des fluides sur la formation des métastases. Médecine Sciences (Paris). 2020 Oct;36(10):872-878

Raphael Gaudin et Jacky G.Goetz. Tracking mechanisms of viral dissemination in vivoTrends in Cell Biology2020 Oct 3;S0962-8924(20)30174-4

Mittelheisser V., Banerjee M., Pivot X., Charbonnière L.J., Goetz J.G., Detappe A. Leveraging immunotherapy with nanomedicineAdvanced Therapeutics. 30 Sept 2020

Benjamin Mary, Shima Ghoroghi, Vincent Hyenne and Jacky G. Goetz. Live tracking of extracellular vesicles in larval zebrafishMethods in Enzymology, in Press 1 Sept 2020

Naël Osmani, Gautier Follain, Valentin Gensbittel, Garcia-Leon MJ, Sébastien Harlepp, Jacky G.Goetz. Probing intravascular adhesion and extravasation of tumor cells with microfluidics. Methods in Molecular Biology, in press

Bing Li , Sébastien Harlepp, Valentin Gensbittel, Connor J. R. Wells, Ophélie Bringel, Jacky G. Goetz, Sylvie Begin-Colin, Mariana Tasso, Dominique Begin, Damien Mertz. NIR-Light Responsive Mesoporous Silica@Carbon Nanotubes for Photothermia and Drug Delivery to Cancer CellsMaterial Today Chemistry. 2020, 17 (2020) 100308

Follain G, Herrmann D, Harlepp S, Hyenne V, Osmani N, Warren SC, Timpson P, Goetz JG. Fluids and their mechanics in tumour transit: shaping metastasis. Nat Rev Cancer. 2020 Feb;20(2):107-124.

2019

Damien Mertz, Sébastien Harlepp, Jacky Goetz, Dominique Bégin, Guy Schlatter, Sylvie Bégin‐Colin, Anne Hébraud. Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering ApplicationsAdvanced Therapeutics2019 (First published: 10 December 2019).

Osmani N, Goetz JG. Multiscale Imaging of Metastasis in Zebrafish. Trends in Cancer. 2019 Dec;5(12):766-778

San Juan BP, Garcia-Leon MJ, Rangel L, Goetz JG, Chaffer CL. The Complexities of Metastasis. Cancers (Basel). 2019 Oct 16;11(10)

Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C, Swift J, Del Campo A, Starborg T, Zech T, Goetz JG, Paluch EK, Schwartz JM, Caswell PT. Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration. Dev Cell. 2019 Nov 18;51(4):460-475

Ayala-Nunez NV, Follain G, Delalande F, Hirschler A, Partiot E, Hale GL, Bollweg BC, Roels J, Chazal M, Bakoa F, Carocci M, Bourdoulous S, Faklaris O, Zaki SR, Eckly A, Uring-Lambert B, Doussau F, Cianferani S, Carapito C, Jacobs FMJ, Jouvenet N, Goetz JG, Gaudin R. Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells. Nat Commun. 2019 Sep 27;10(1):4430

Naël Osmani, Gautier Follain, Marìa Jesùs Garcia Leòn, Olivier Lefebvre, Ignacio Busnelli, Annabel Larnicol, Sébastien Harlepp, Jacky G. Goetz. Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest. Cell Reports, 2019, Sep 3;28(10):2491-2500

Verweij FJ, Hyenne V, Van Niel G, Goetz JG. Extracellular Vesicles: Catching the Light in Zebrafish. Trends in Cell Biology Aug 7. pii: S0962-8924(19)30123-0

Hyenne V, Ghoroghi S, Collot M, Bons J, Follain G, Harlepp S, Mary B, Bauer J, Mercier L, Busnelli I, Lefebvre O, Fekonja N, Garcia-Leon MJ, Machado P, Delalande F, López AA, Silva SG, Verweij FJ, van Niel G, Djouad F, Peinado H, Carapito C, Klymchenko AS, Goetz JG. Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo. Developmental Cell. 2019 Feb 4. pii: S1534-5807(19)30014-0

Verweij FJ, Revenu C, Arras G, Dingli F, Loew D, Pegtel MD, Follain G, Allio G, Goetz JG, Zimmermann P, Herbomel P, Del Bene F, Raposo G, van Niel G. Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo. Developmental Cell. 2019 Feb 5. pii: S1534-5807(19)30004-8

Francis Perton, Sébastien Harlepp, Gautier Follain, Jacky G. Goetz, Sylvie Bégin-Colin, Damien Mertz. Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo. Journal of Colloid and Interface Science. 2019, Jan 23, 542:469-482

2018

Chaffer CL, Goetz JG. CD44 Orchestrates Metastatic Teamwork Developmental Cell • Dec 17, 2018

Goetz JG. Metastases go with the flow Science • November 30, 2018

Goetz JG. Exploiting Anatomical Landmarks for Efficient In Vivo CLEM Trends in Biochemical Sciences • August 17, 2018

Mammadova-Bach E, Rupp T, Spenlé C, Jivkov I, Shankaranarayanan P, Klein A, Pisarsky L, Méchine-Neuville A, Cremel G, Kedinger M, De Wever O, Ambartsumian N, Robine S, Pencreach E, Guenot D, Simon-Assmann P, Goetz JG, Orend G, Lefebvre O. Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. Biology of the Cell • June 15, 2018

Ezzoukhry Z, Henriet E, Cordelières FP, Dupuy JW, Maître M, Gay N, Di-Tommaso S, Mercier L, Goetz JG, Peter M, Bard F, Moreau V, Raymond AA, Saltel F. Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation Nature Communication • June 15, 2018

Follain G, Goetz JG. Synergistic Mechano-Chemical Sensing by Vascular Cilia Trends in Cell Biology • May 2, 2018

Gautier Follain, Nael Osmani, Sofia Azevedo, Guillaume Allio, Luc Mercier, Matthia Karreman, Gergely Solecki, Nina Fekonja, Claudia Hille, Vincent Chabannes, Guillaume Dolle, Thibaut Metivet, Christophe Prudhomme, Bernhard Ruthensteiner, Andre Kemmling, Susanne Siemonsen, Tanja Schneider, Jens Fiehler, Markus Glatzel, Frank Winkler, Yannick Schwab, Klaus Pantel, Sebastien Harlepp, Jacky G. Goetz. Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells Developmental Cell • April 9, 2018

Follain G, Osmani N, Fuchs C, Allio G, Harlepp S, Goetz JG. Using the Zebrafish Embryo to Dissect the Early Steps of the Metastasis Cascade Cell Migration • March 11, 2018

Naël Osmani, Julien Pontabry, Jordi Comelles, Nina Fekonja, Jacky G Goetz, Daniel Riveline, Elisabeth Georges-Labouesse, Michel Labouesse. An Arf6- And Caveolae-Dependent Pathway Links Hemidesmosome Remodeling And Mechanoresponse. Molecular Biology of the Cell • February 15, 2018

2017

Carapito R, Konantz M, Paillard C, Miao Z, Pichot A, Leduc MS, Yang Y, Bergstrom KL, Mahoney DH, Shardy DL, Alsaleh G, Naegely L, Kolmer A, Paul N, Hanauer A, Rolli V, Müller JS, Alghisi E, Sauteur L, Macquin C, Morlon A, Sancho CS, Amati-Bonneau P, Procaccio V, Mosca-Boidron AL, Marle N, Osmani N, Lefebvre O, Goetz JG, Unal S, Akarsu NA, Radosavljevic M, Chenard MP, Rialland F, Grain A, Béné MC, Eveillard M, Vincent M, Guy J, Faivre L, Thauvin-Robinet C, Thevenon J, Myers K, Fleming MD, Shimamura A, Bottollier-Lemallaz E, Westhof E, Lengerke C, Isidor B, Bahram S. Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond–like features. JCI • October 3, 2017

Harlepp S, Thalmann F, Follain G, Goetz JG.Hemodynamic forces can be accurately measured in vivo with optical tweezers. MBoC • September 13, 2017

Bohdan Andreiuk, Andreas Reisch, Marion Lindecker, Gautier Follain, Nadine Peyriéras, Jacky G. Goetz, Andrey S. Klymchenko. Fluorescent Polymer Nanoparticules for Cell Barcoding in Vitro et in Vivo. Small • August 9, 2017

Matthia A. Karreman, Bernhard Ruthensteinerx, Luc Mercier, Nicole L. Schieber, Gergely Solecki, Frank Winkler, Jacky G. Goetz, Yannick Schwab. Find your way with X-ray: Using microCT to correlate in vivo imaging with 3D electron microscopy. Methods in Cell Biology • April 21, 2017

EV-TRACK Consortium. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nature Methods • March, 2017

Vincent Hyenne, Jacky G Goetz. Extracellular vesicles on a wire. Cell Adhesion and Migration, Volume 11 – Issue 2 • March 4, 2017

Vincent Hyenne, Olivier Lefebvre, Jacky G Goetz. Going live with tumor exosomes and microvesicules. Cell Adhesion and Migration • March 4, 2017

E. Mammadova-Bach, T. Rupp, C. Spenle, I. Jivkov, P. Shankaranarayanan, A. Klein, L. Pisarsky, A. Méchine-Neuville, G. Cremel, M. Kedinger, O. De Wever, N. Ambartsumian, S. Robine, E. Pencreach, D. Guenot, J.G. Goetz*, P. Simon-Assmann,G. Orend* and O. Lefebvre* (* Co-corresponding authors). Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma Biorxiv • Posted January 10, 2017 by J.G Goetz

Gautier Follain, Luc Mercier, Naël Osmani, Sébastien Harlepp, Jacky G. Goetz. Seeing is believing: multi-scale spatio-temporal imaging towards in vivo cell biology Journal of Cell Science • Janvier 1, 2017

2016

Tristan Rupp, Benoit Langlois, Maria M. Koczorowska, Agata Radwanska, Zhen Sun, Thomas Hussenet, Olivier Lefebvre, Devadarssen Murdamoothoo, Christiane Arnold, Annick Klein, Martin L. Biniossek, Vincent Hyenne, Elise Naudin, Ines Velazquez-Quesada, Oliver Schilling, Ellen Van Obberghen-Schilling, and Gertraud Orend* Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling Cell Reports • December, 2016

Vincent Hyenne, Michel Labouesse, Jacky G Goetz. The small GTPases Ral orchestrates MVB biogenesis and exosome secretion. Small GTPases • November, 2016

Matthia A. Karreman, Vincent Hyenne, Yannick Schwab, Jacky G. Goetz. Intravital Correlative Microscopy: Imaging Life at the Nanoscale Trends in Cell Biology • November, 2016

Jacob L, Sawma P, Garnier N, Meyer LA, Fritz J, Hussenet T, Spenlé C, Goetz JG, Vermot J, Fernandez A, Baumlin N, Aci-Sèche S, Orend G, Roussel G, Crémel G, Genest M, Hubert P, Bagnard D. Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide. Oncotarget • Sept., 2016

Redouane Bouchaala, Luc Mercier, Bohdan Andreiuk , Yves Mély, Thierry Vandamme, Nicolas Anton*, Jacky G. Goetz* and Andrey S. Klymchenko* (equal contribution for RB & LM, *co-corresponding authors). Integrity of lipid nanocarriers in bloodstream and tumor quantified by near-infrared ratiometric FRET imaging in living mice. Journal of Controlled Release • August, 2016

Luc Mercier, Johann Böhm, Nina Fekonja, Guillaume Allio, Yves Lutz, Marc Koch, Jacky G. Goetz, Jocelyn Laporte. In vivo imaging of skeletal muscle in mice highlights muscle defects in a model of myotubular myopathy IntravitalApr 06, 

Julie Di Martino, Elodie Henriet, Zakaria Ezzoukhry, Jacky G. Goetz, Violaine Moreau, Frederic Saltel.The microenvironment controls invadosome plasticity. Journal of Cell ScienceMar 30, doi: 10.1242/jcs.182329

Matthia A. Karreman, Luc Mercier, Nicole L. Schieber, Gergely Solecki, Guillaume Allio, Frank Winkler, Bernhard Ruthensteiner, Jacky G. Goetz*, Yannick Schwab* (co-corresponding authors)Fast and precise targeting of single tumor cells in vivo by multimodal correlative microscopy Journal of Cell Science • 129: 444-456

2015

Vincent Hyenne, Ahmet Apaydin, David Rodriguez, Coralie Spiegelhalter, Sarah Hoff-Yoessle, Maxime Diem, Saurabh Tak, Olivier Lefebvre, Yannick Schwab, Jacky G. Goetz and Michel Labouesse. RAL-1 controls multivesicular body biogenesis and exosome secretion Journal of Cell Biology • 2015 211:27-37

Tello M, Spenlé C, Hemmerlé J, Mercier L, Fabre R, Allio G, Simon-Assmann P, Goetz JG. Generating and characterizing the mechanical properties of Cell-Derived Matrices using Atomic Force Microscopy. Methods • October, 2015 (Epub ahead of print)

Caballero D, Goetz JG. Foreword: Physics of cell migration. Cell Adhesion and Migration • 2015 Aug 27:1-2.

Azevedo AS, Follain G, Patthabhiraman S, Harlepp S, Goetz JG. Metastasis of circulating tumor cells: Favorable soil or suitable biomechanics, or both?Cell Adhesion and Migration • 2015 Aug 27:1-12.

Hidalgo A, Goetz JG. Multicellular cuddling in a stem cell niche. Cell Adhesion and Migration • 2015 Jul 4;9(4):280-2.

Maurer E, Schaff M, Receveur N, Bourdon C, Mercier L, Nieswandt B, Dubois C, Jandrot-Perrus M, Goetz JG, Lanza F, Gachet C, Mangin PH. Fibrillar cellular fibronectin supports efficient platelet function and procoagulant activity. Thrombosis Haemostasis  2015 Aug 6;114(6)

Boselli F, Goetz JG, Charvin G, Vermot J. A quantitative approach to study endothelial cilia bending stiffness during blood flow mechanodetection in vivo. Methods in Cell Biology  2015;127:161-73

J.G. Goetz, F.Monduc, Y. Schwab and J. Vermot. Using correlative light and electron microscopy to study zebrafish vascular morphogenesis. Methods in Molecular Biology • 2015;1189:31-46

2014

Matthia A. Karreman, Luc Mercier, Nicole L. Schieber, Tsukasa Shibue, Yannick Schwab, Jacky G. Goetz.  Correlating Intravital Multi-Photon Microscopy to 3D Electron Microscopy of Invading Tumor Cells Using Anatomical Reference Points Plos One • 2014

J.G. Goetz, E. Steed, R.R. Ferreira, S. Roth, C. Ramspacher, F. Boselli, G. Charvin, M. Liebling, C. Wyart, Y. Schwab, J. Vermot. Endothelial cilia mediate low flow sensing during zebrafish vascular development Cell Reports • 20145:799-808

2012

J.G. Goetz Editorial from Guest Editor : Tumor microenvironment indoctrination: An emerging hallmark of Cancer Cell Adhesion and Migration•2012•6:1-3

J.B. Freund, J.G. Goetz, K.Hilland J.Vermot Biophysical principles in developmental microfluidics Development•2012•139:1224-1236

2011

J.G. Goetz*, S.Minguet, I.Navarro-Lérida, J.J.Lazcano, R.Samaniego, E.Calvo, M.Tello, T.Osteso-Ibáñez, T.Pellinen, A.Echarri, A.Cerezo, A.J.P. Klein-Szanto, R.Garcia, P.J. Keely, P.Sánchez-Mateos, E.Cukierman and M.A. Del Pozo*. (* Co-corresponding authors) Biomechanical remodeling of the microenvironment by stromal Cav1 favors tumor invasion and metastasis Cell2011146:148-163 (Selected for the PaperFlick on Cell website, Highlighted in Nature, Nature Reviews Cancer, Nature’s Cell migration gateway, F1000-FFa=12, Extracelllular Matrix News)

J.G. Goetz* and M.A. Del Pozo*. (* Co-corresponding authors) Caveolin-1 forces matrix remodeling / La cavéoline-1 force le remodelage de la matrice extracellulaire Médecine/Sciences•2011• 11: 940-944

2009

A. Cerezo, M.C. Guadamillas, J.G. Goetz, S. Sánchez-Perales, E. Klein, R. K. Assoian and M. A. del Pozo. Absence of Caveolin-1 Increases Proliferation and Anchorage-Independent Growth by a Rac-Dependent, Erk-Independent Mechanism Molecular and Cellular Biology • 20099:5046-5059

B. Joshi, S.S. Strugnell, J.G. Goetz, L.D. Kojic, M.E. Cox, O.l. Griffith, S.k. Chan, S.j. Jones, S.p. Leung, H. Masoudi, S. Leung, S.m. Wiseman and I.R. Nabi. Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion Cancer Research • 200868:8210-8220.

J.G. Goetz*, P. Lajoie*, J.W. Dennis and I.R. Nabi (* equal contribution) Lattices, rafts and scaffolds: domain regulation of receptor signaling at the plasma membrane Journal of Cell Biology • 2009 • 185:381-385

J.G. Goetz Bidirectional control of the inner dynamics of focal adhesions promotes cell migration Cell Adhesion and Migration• 2009 • 3:185-190

2008

J.G. Goetz, B. Joshi, P. Lajoie, S.S. Strugnell, T. Scudamore, L.D. Kojic and I.R. Nabi Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine phosphorylated caveolin-1 Journal of Cell Biology2008 180: 1261-1275 (Highlighted in Nature’s Functional Glycomics Gateway, F1000-FFa=8).

J.G. Goetz*, P. Lajoie*, S.M.Wiseman and I.R. Nabi (* equal contribution) Caveolin-1 in tumor progression : the good, the bad and the ugly Cancer and Metastasis Reviews • 2008 • 27:715-735

2007

J.G. Goetz*, H.Genty*, P. St-Pierre*, T. Dang, R. Sauvé, W. Vogland I.R. Nabi (* equal contribution) Reversible interactions between smooth endoplasmic reticulum and mitochondria are regulated by physiological cytosolic calcium levels Journal of Cell Science • 2007 120:3553-3564 (Selected for cover image)

P. Lajoie, E. Partridge, G. Guay, J.G. Goetz, J. Pawling, A.Lagana, B.Joshi, J.W. Dennis and I.R. Nabi Plasma membrane domain organization regulates EGFR signaling in tumor cells Journal of Cell Biology • 2007 179:341-356 (Selected for cover image and highlighted in JCB’s In this issue, Nature’s Functional Glycomics Gateway and F1000-FFa=10)

2006

A. Lagana*, J.G. Goetz*, P. Cheung, A.Raz, J.W. Dennis, and I.R. Nabi. (* equal contribution) Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells. Molecular and Cellular Biology • 2006 • 26:3181-3193 (Selected for cover image).

J.G. Goetz and I.R. Nabi. Interaction of the smooth endoplasmic reticulum and mitochondria Biochemical Society Transactions • 2006 • 34:370-373

2005

A. Lagana, J.G. Goetz, N.Y, Y. Altschuler, and I.R. Nabi pH specific sequestration of phosphoglucose isomerase/autocrine motility factor/neuroleukin by fibronectin Journal of Cell Science• 2005 • 118:4175-4185 (Selected for cover image)

2004

M. Registre, J.G. Goetz, P. St Pierre, H. Pang, M. Lagace, M/ Bouvier, P. Le, I.R. Nabi. The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum Biochemical Biophysical Research Communication2004 • 320:1316-1322