Jacky G. GOETZ
DR INSERM, Leader
Jacky graduated in Pharmacology and Cell Biology from University of Strasbourg (France) where he studied astrocytoma cell migration in the laboratory of Ken TAKEDA. He then moved to the laboratory of Ivan Robert NABI in Montreal (University of Montreal, Canada), and later in Vancouver (University of British Columbia, Canada), where he first studied the interaction between the endoplasmic reticulum and mitochondria. He was in parallel interested in glycosylation of membrane proteins, in particular integrins, and described its importance, in concert with Caveolin-1 (Cav1), in fibronectin fibrillogenesis, focal adhesion dynamics and tumor cell migration. He received his Ph.D. degree in 2007 from both University of Montreal and University of Strasbourg. He then moved to the CNIC in Madrid (Spain) in the laboratory of Miguel Angel del Pozo where he led a study on the implication of Cav1 in biomechanical remodeling of the microenvironment and showed its importance in normal tissue architecture but especially during tumor progression. He then joined the team of Julien VERMOT at the IGBMC in Strasbourg (France) to pursue his interests in mechanotransduction phenomenons using zebrafish as a model. He recently won the « SBCF young scientist » prize for his contribution to Cell Biology and started his team « Tumor Biomechanics » in 2013 where he develops his growing interest for the role played by biomechanical forces during tumor progression. He could « kill » for sushi and loves the alsatian architecture.
After getting successfully his DEA in 1990, Olivier started his PhD in Paul Basset and Marie-Chiristine Rio team at IGBMC, establishing animal models in order to understand the function of two genes, the stromelysin-3 (MMP-11) and TFF1 (pS2), implicated in breast cancer. In 1995 he started a post-doctoral fellow at Inserm U381 in Patricia-Simon Assmann team, on the role of basement membrane molecule, especially Laminins, in normal and pathological intestine. Two years after, he was recruited as Inserm scientist focusing his research on Laminin 111 isoform in organ development and tumorigenesis. In 2003 he joined the Inserm-MN3t team, directed by Gertraud Orend, working on the role of extracellular matrix, mainly Laminin 111 and Tenascin-C, on angiogenesis during cancer progression.
Vincent Hyenne did his PhD in Jussieu, Paris on epithelial polarity in mouse early embryonic development. He then moved to IRIC (Montreal, Québec) where he studied the establishment of cell polarity, and its link with vesicular trafficking, using C. elegans embryo as a model system. Back in France at the IGBMC (Illkirch), he got fascinated by exosomes and extracellular vesicles (EVs) and identified new genes required for their secretion in C. elegans. He joined Jacky’s team to study EVs in the context of tumor progression, using intravital imaging correlated to electron microscopy. Vincent loves to play (watch) basketball while reading a good book and drinking a good wine.
Sebastien Harlepp was sweating during his PhD in Strasbourg studying RNA folding at the single molecule level. He then moved to U of Chicago where he studied the RNA expression at the single cell level using fluorescent correlation spectroscopy. Back in France at IPCMS (Strasbourg) as an associate professor, he developed physical tools to study molecular interaction at the single molecule and single cell level. In the meantime, he started studying blood flow in zebrafish embryos. He joined Jacky’s team to study the impact of blood flow and mechanical stress on extravasation and metastatic formation.
It’s not because I’m wandering that I’m lost…
Naël did his PhD in the lab of Sandrine Etienne-Manneville at Curie and then Pasteur institutes in Paris, working on the Cdc42-dependent regulation of polarity during cell migration. He then moved to Strasbourg and joined the lab of Michel Labouesse at IGBMC where he studied the role of Arf6-dependent traffic and caveolin 1 in the regulation of epithelial integrin adhesions and their mechanoresponse. In Jacky’s lab, he is interested in the role of cell adhesions during tumor cell extravasation. Outside of the lab, he is a big fan of martial arts and has been practicing kung-fu for 15 years. He also loves killing some time watching movies or reading.
Maria G. LEON
María, originally from Spain, did her PhD in the lab of María L. Toribio at the Molecular Biology Center Severo Ochoa (CMB) and graduated with honors in Immunology and Molecular Biology by the Autónoma University of Madrid. She studied the Notch signalling crosstalk within the human thymic niche and its contribution to normal lymphocyte development and leukemia pathogenesis. At Jacky’s lab she is interested in depicting the role of biomechanical forces and blood cells (such as platelets) in acute lymphocytic leukemia (ALL) cell infiltration. Her commitment with Science goes out of the lab as she loves teaching Biology to kids and students, and it is often involved in science public engagement events. She also loves practicing and watching boxing and likes to follow the American UFC ligue of mixed martial arts.
Nandini from India, obtained her Masters degree in Molecular Bioengineering, from Technical Univerity of Dresden, Germany. She did her PhD in the lab of Prof. Dr. Martin Bornhäuser, Stem cell lab, Dresden. For her graduate work, she established and characterized an ‘embryonic zebrafish xenograft model’ using high resolution selective plane illumination microscopy (SPIM). Further validated the model using known drug and screened for few candidates that target tumor cell migration and invasion. Upon graduating, She got interested to understand the role of host immune cells towards the incoming tumor cells in-depth. Towards this end, she joined Jacky’s team to study the impact of extracellular vesicles and immune cells in metastatic outgrowth using zebrafish. She has been actively involved in ‘Science goes to School’ projects to spread science in young minds. She likes to play Cricket, an avid Boardgamer, follows premier league games, if nothing is there, she kills her boredom with her cooking experiments
Shared Post-Doctoral Fellow
Katerina Jerabkova (Katka), originally from Czech Republic, did a double degree PhD program between the Charles University (Prague) and the University of Strasbourg. She studied the role of ubiquitin signaling in the regulation of cell division. Using live-video and super resolution microscopy she described a novel factor controlling mitotic progression and thus euploidy of human cells. She became interested in how cancer cells differ from the cells of healthy tissues and for this purpose she joined the Nanotumor project. This collaborative effort aims to answer those questions by studying the cancer cell morphology and signaling pathways. When not in the lab she likes to run and paint.
After studying biology at J. Rostand high school in Strasbourg and getting a diploma in 1989, Annabel got a permanent position at INSERM in1990. She then joined J.-M. Egly team at the IGBMC and worked there for more than 25 years. Her expertise in molecular biology allowed her to become a specialist in in vitro transcription assay. She participated to the purification and identification of keys elements of the transcription machinery. Recently she decided to challenge herself and totally changed her professional environment by joining Jacky Goetz’s team in August 2018. She hates cooking, loves the crossfit and never refuses to have drinks with friends.
Electron Microscopy Engineer
Ignacio Busnelli from Argentina, gets a Bachelor’s degree in Biotechnology from the National University of Tucuman. He started with the Transmision electron microscopy few years ago at Integral Center for Electron Microscopy (CIME) in Tucuman. First it was out of curiosity and after a while he realized how exciting was this profession. He took the EMBO course in 2016 in Czech Republic where he learned how many things could be done in this amazing field and how great it would be to be able to do it by hisself. He joined recently Jacky’s team to collaborate whith his knowledge in ultramicrotomy and MET and to keep learning. He is from the motto « let’s do it ». He is a hobbyist photographer, he loves traveling and knowing places and nice people. (@busnelliIgnacio)
NANOTUMOR project manager
Florent Colin studied at the Faculty of Biology of the University of Strasbourg, specialising in molecular biology and biochemistry. After his Master 2 in the team of Dr. Irwin Davidson (IGBMC – 2008), he joined the team of Dr. Hélène Puccio to do his thesis on the implication of iron-sulfur cluster biosynthesis in the rare neurodegenerative disease called Friedreich’s ataxia, in collaboration with Dr. Sandrine Ollagnier-deChoudens (IGBMC, Strasbourg & CEA, Grenoble – 2013). He then joined the team of Pr. Jean-Louis Mandel and then Pr. Jamel Chelly (IGBMC – until now) as project leader of GENIDA (https://genida.unistra.fr/), a participatory and international study on genetic forms of neurodevelopmental disorders. He has recently joined the team of Dr. Jacky Goetz (TUMOR Biomechanics lab, Strasbourg) as project leader of NANOTUMOR (https://nanotumor.fr). (@NANOTUMOR)
Shima graduated with a Bachelor’s degree in biology from the State University of New York at Purchase. As a graduate student at the City University of New York at Lehman, her research focus was to define signaling between neural stem cells. She designed methods to identify and quantify cell state and the release of exosomes. To continue her research in exosomes, she decided to join Jacky’s team for her PhD. Besides research in science, shima is also interested in Persian miniature painting. She believes science is an art.
Benjamin obtained his bachelor’s degree at the University of Strasbourg, during which he chose to spend one year at the University of Montreal in student exchange program, where he discovered the warmhearted atmosphere of Quebec. Back to France, he spent one Master year studying Health Biology in Paris. Then, he moved to Strasbourg, his hometown, in order to do a master’s degree in Developmental and Stem Cell Biology. While spending two months in Jacky’s lab (M1 internship), he fell in love with the wonderful world of Extracellular Vesicles, working closely with Vincent Hyenne. He decided to continue his journey in this field. He did his second internship (M2) in the team and continue as PhD student in the tumor biomechanics lab, working on tumor Extracellular Vesicles and their link with metastasis formation. Ben defines his self as a meat-eater vegan-friendly.
Valentin was born and raised in Alsace, where he spent his youth in a tiny village. After high school, he discovered the citizen lifestyle when he moved to Strasbourg in order to study biology. He obtained his Bachelor’s in « Cellular Biology and Physiology » in 2017 and decided to follow up with a Master’s degree in « Developmental Biology and Stem Cells ». During the first year of his degree, he became interested in cancer biology and dedicated a lot of bibliographical work to this particular subject. He saw an opportunity to work on similar interesting topics when he found Jacky’s lab. He joined the team as a Master student in September 2018 and dedicated his internship to studying the importance of cell stiffness on metastatic progression. Outside of the lab, Valentin likes to spend his time watching movies at the theatre or spectacular english Premier League football games on the week-ends.
In parallel of his pharmacy studies, Vincent decided to do a Master degree. He spent one Master year studying “Pharmaceutical biotechnologies” in Illkirch. Then, after a Master 1 internship in Kastner & Chan’s lab at the IGBMC studying the transcriptional regulation of early hematopoiesis, he chose to do a Master 2 degree in « Immunology and Inflammation ». Through these experiences, he became interested in cancer immunotherapy. Vincent joined the team as a Master 2 student in September 2019 in collaboration with the Detappe’s lab at the Centre Paul Strauss. He dedicated his internship to develop bispecific simili CAR-NK immune cells. Outside of the lab, Vincent likes to spend his time watching series, listing to music and (sometimes) going to the opera or museums.
Cynthia has always been attracted to biology and she obtained a Baccalauréat scientifique in 2012. It’s in the Faculty of Life Sciences in Strasbourg where she found her preferred field: developmental biology. She obtained her degree in « Molecular and Cellular Biology » in 2018 and joined the Master in « Molecular Genetics of Development and Stem Cells ». Although she was already interested in oncology before, she only discovered this field later in her first year of her Master’s degree. She joined Jacky Goetz’s team in September 2020 for her second year master’s internship. Passionate about history, Cynthia does historical re-enactment by sewing outfits and studying weaving, sewing and dyeing techniques with a Viking company in her spare time. She is also attracted to music and participates in many concerts and festivals by supporting local groups.
Isabelle has been working in INSERM units for many years. Since 1980, she travelled from U61, to U381, to U682 and finally U1109. During these years, she mostly assisted the unit director. Within U1109, she drastically changed daily tasks and is now taking care of the ordering, the budget and human resources, and she is good at it ! Outside the lab/office, she enjoys cooking home-made garden products and they are good !